Autoimmune Inflammatory Diseases

Autoimmune inflammatory diseases occur when the body's immune system mistakenly attacks healthy tissue, causing chronic inflammation that damages the skin as well as internal organs.

The good news is that with early diagnosis and modern immunomodulating treatment, people with these conditions can now control their symptoms and keep living full, active lives.

Our Approach to Treating Autoimmune Disease

Our specialists lead the way in diagnosis and treatment, using techniques such as digital dermoscopy to study the fine structure of blood vessels and skin biopsy to pin down exactly what kind of inflammation is present. You can rely on the team at Haute-Derma for an accurate diagnosis and an effective treatment plan tailored to your particular condition.

We offer a complete cycle of care for autoimmune disease, including:

Recognizing risk factors early and heading off flares at the very first stage.

Comprehensive disease management that combines topical treatment with systemic immunomodulation.

Multispecialty screening, with referral to gastroenterology, rheumatology or hematology specialists when the disease involves internal organs.

Comprehensive Lifelong Management of Autoimmune Disease

Autoimmune disease is a complex chronic condition that can take a heavy physical and emotional toll on you and your family.

Our specialists provide continuous, patient-centered care from the moment of diagnosis and for the rest of your life.

To keep the disease from worsening, our specialty clinic closely follows you after each acute treatment phase so that inflammation stays under steady control.

We understand that you want to live well alongside your condition. Our specialists encourage self-care by helping you understand how the disease works and how it affects your daily life. We also use advanced technology to monitor you remotely, so we can step in quickly at the first sign of a flare.

Types of Autoimmune Inflammatory Diseases

Schnitzler Syndrome

Cryopyrin-Associated Periodic Syndromes (CAPS)

A rare disorder combining chronic hives, recurrent fever, bone and joint pain and a monoclonal gammopathy in the blood.

A group of conditions caused by NLRP3 gene mutations, with recurrent fevers, a non-itchy hive-like rash and a risk of hearing loss or systemic amyloidosis.

CARD14-Mediated Pustular Psoriasis (PSORS2)

Deficiency of the Interleukin-36 Receptor Antagonist (DITRA)

Psoriasis or pustular psoriasis caused by CARD14 mutations, which keep inflammatory pathways in skin cells permanently switched on.

A recurrent, acute form of generalized pustular psoriasis caused by IL36RN mutations, with bouts of high fever and sterile pustules on red skin.

TNF Receptor-Associated Periodic Syndrome (TRAPS)

Mevalonate Kinase Deficiency (MKD)

Also called hyper-IgD syndrome; causes prolonged fevers from early childhood with swollen neck nodes, mouth ulcers and varied skin rashes.

The inherited fever syndrome with the longest attacks (often more than 7 days), with muscle pain, swelling around the eyes and red patches that travel along the limbs.

CANDLE Syndrome

OTULIN-Related Autoinflammatory Syndrome (ORAS)

A rare proteasome-related disorder with daily fevers, thick swollen lips, loss of facial fat (lipodystrophy) and persistent violaceous skin plaques.

Severe systemic inflammation starting very early in life, marked by fever, persistent diarrhea and painful inflamed nodules in the fat under the skin.

Majeed Syndrome

PAPA Syndrome

A rare inherited disease combining chronic recurrent osteomyelitis, congenital dyserythropoietic anemia and neutrophilic skin disorders.

A syndrome affecting joints and skin, with sterile arthritis, severe acne and recurrent pyoderma gangrenosum.

Types of Autoimmune Inflammatory Diseases

Cryopyrin-Associated Periodic Syndromes (CAPS)

A group of conditions caused by NLRP3 gene mutations, with recurrent fevers, a non-itchy hive-like rash and a risk of hearing loss or systemic amyloidosis.

Schnitzler Syndrome

A rare disorder combining chronic hives, recurrent fever, bone and joint pain and a monoclonal gammopathy in the blood.

Deficiency of the Interleukin-1 Receptor Antagonist (DIRA)

A life-threatening condition that begins in newborns, with widespread bone inflammation and a generalized pustular rash driven by unchecked IL-1 activity.

Deficiency of the Interleukin-36 Receptor Antagonist (DITRA)

A recurrent, acute form of generalized pustular psoriasis caused by IL36RN mutations, with bouts of high fever and sterile pustules on red skin.

CARD14-Mediated Psoriasis

Psoriasis or pustular psoriasis caused by CARD14 mutations, which keep inflammatory pathways in skin cells permanently switched on.

Familial Mediterranean Fever

The most common autoinflammatory syndrome, with short, recurring fevers, serositis (abdominal or chest pain) and an erysipelas-like rash on the legs.

Mevalonate Kinase Deficiency

Also called hyper-IgD syndrome; causes prolonged fevers from early childhood with swollen neck nodes, mouth ulcers and varied skin rashes.

TNF Receptor-Associated Periodic Syndrome (TRAPS)

The inherited fever syndrome with the longest attacks (often more than 7 days), with muscle pain, swelling around the eyes and red patches that travel along the limbs.

Haploinsufficiency of A20 (HA20)

A Behçet-like autoinflammatory disease with recurrent mouth and genital ulcers and arthritis, caused by a shortage of the regulatory protein A20.

OTULIN-Related Autoinflammatory Syndrome (ORAS)

Severe systemic inflammation starting very early in life, marked by fever, persistent diarrhea and painful inflamed nodules in the fat under the skin.

CANDLE Syndrome

A rare proteasome-related disorder with daily fevers, thick swollen lips, loss of facial fat (lipodystrophy) and persistent violaceous skin plaques.

Blau Syndrome

An inherited disorder defined by a triad of uveitis, arthritis and a rash of small granulomatous papules in children under 4.

PAPA Syndrome

A syndrome affecting joints and skin, with sterile arthritis, severe acne and recurrent pyoderma gangrenosum.

Majeed Syndrome

A rare inherited disease combining chronic recurrent osteomyelitis, congenital dyserythropoietic anemia and neutrophilic skin disorders.

SAPHO Syndrome

A cluster of synovitis, severe acne, pustulosis of the palms and soles, hyperostosis and osteitis, usually affecting the breastbone area and spine.

Frequently Asked Questions About Autoimmune Inflammatory Diseases

Experiencing similar symptoms?

Our Haute-Derma specialists are ready to provide expert consultation on Autoimmune Inflammatory Diseases — from accurate diagnosis to the most suitable treatment plan for you.

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